Versatile Effects of Aurone Structure on Mushroom Tyrosinase Activity (pages 559–565)
Carole Dubois, Romain Haudecoeur, Dr. Maylis Orio, Dr. Catherine Belle, Dr. Constance Bochot, Prof. Ahcène Boumendjel, Dr. Renaud Hardré, Dr. Hélène Jamet and Dr. Marius Réglier
Article first published online: 3 FEB 2012 | DOI: 10.1002/cbic.201100716
Inhibitor development: We have highlighted the extraordinary versatile effects of the aurone structure on mushroom Ty activity. Depending on the position of the OH group on the B-ring, aurones can behave either as substrates or as activator. We also synthesized and evaluated a compound combining an aurone moiety with HOPNO, an efficient inhibitor for mushroom Ty (Kiu=1.62 μM and Kic=1.27 μM).