Flexible and General Synthesis of Functionalized Phosphoisoprenoids for the Study of Prenylation in vivo and in vitro (pages 674–683)
Dr. Debapratim Das, Zakir Tnimov, Dr. Uyen T. T. Nguyen, Dr. Govindaraju Thimmaiah, Dr. Harriet Lo, Dr. Daniel Abankwa, Dr. Yaowen Wu, Prof. Dr. Roger S. Goody, Prof. Dr. Herbert Waldmann and Prof. Dr. Kirill Alexandrov
Article first published online: 20 FEB 2012 | DOI: 10.1002/cbic.201100733
Prenylation probes: Eukaryotic protein prenyltransferases modify polypeptides with isoprenoid lipids. Modification of isoprenoids with reporter groups allows the creation of probes for the analysis of protein prenylation in vitro and in vivo. An amine-derivatized isoprenoid scaffold was used as a novel starting point for the synthesis of functionalized phosphoisoprenoid libraries.