Unusual Tubulin-Clustering Ability of Specifically C7-Modified Colchicine Analogues (pages 1444–1449)
Dr. Olga N. Zefirova, Heiko Lemcke, Dr. Margareta Lantow, Dr. Evgeniya V. Nurieva, Birgit Wobith, Prof. Galina E. Onishchenko, Antje Hoenen, Prof. Gareth Griffiths, Prof. Nikolay S. Zefirov and Dr. Sergei A. Kuznetsov
Article first published online: 10 JUL 2013 | DOI: 10.1002/cbic.201300143
Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.