Fluorinated Pseudopeptide Analogues of the Neuropeptide 26RFa: Synthesis, Biological, and Structural Studies (pages 1620–1633)
Dr. Camille Pierry, Dr. Samuel Couve-Bonnaire, Dr. Laure Guilhaudis, Dr. Cindy Neveu, Amélie Marotte, Benjamin Lefranc, Dr. Dominique Cahard, Prof. Isabelle Ségalas-Milazzo, Dr. Jérôme Leprince and Prof. Xavier Pannecoucke
Article first published online: 12 AUG 2013 | DOI: 10.1002/cbic.201300325
Fluoro-olefin in place of a peptide: Dipeptides analogues containing a fluoro-olefin moiety in place of the peptide bond have been synthesized and introduced into the bioactive C-terminal heptapeptide of the neuropeptide 26RFa by SPPS. The fluoro-olefin moiety is an effective mimic of the peptide bond that enhances peptide stability, has little impact on its conformation and slightly better bioactivity.