Heparin Modulates the Mitogenic Activity of Fibroblast Growth Factor by Inducing Dimerization of its Receptor. A 3D View by Using NMR (pages 1732–1744)
Dr. Lidia Nieto, Dr. Ángeles Canales, Dr. Israel S. Fernández, Dr. Elena Santillana, Dr. Rocío González-Corrochano, Dr. Mariano Redondo-Horcajo, Prof. F. Javier Cañada, Dr. Pedro Nieto, Prof. Manuel Martín-Lomas, Prof. Guillermo Giménez-Gallego and Prof. Jesús Jiménez-Barbero
Article first published online: 12 AUG 2013 | DOI: 10.1002/cbic.201300313
Held together with a hairpin: A structural explanation of the modulation of FGF-driven mitogenesis by heparin and heparan sulfate is given. Full enhancement occurs when heparin is previously incubated with the receptors, which then dimerize and adopt the relative conformation present in the complete signaling complex.