An Enzymatic Route to Selenazolines (pages 564–567)
Dr. Jesko Koehnke, Falk Morawitz, Andrew F. Bent, Dr. Wael E. Houssen, Dr. Sally L. Shirran, Dr. Matthew A. Fuszard, Dr. Iain A. Smellie, Dr. Catherine H. Botting, Prof. Margaret C. M. Smith, Prof. Marcel Jaspars and Prof. James H. Naismith
Version of Record online: 18 FEB 2013 | DOI: 10.1002/cbic.201300037
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.