Opposite Modulation of Cell Migration by Distinct Subregions of Urokinase Connecting Peptide (pages 882–889)
Dr. Paola Franco, Prof. Alfonso Carotenuto, Dr. Cristina Marcozzi, Dr. Giuseppina Votta, Dr. Ciro Sarno, Dr. Ingram Iaccarino, Dr. Diego Brancaccio, Dr. Anna De Vincenzo, Prof. Ettore Novellino, Prof. Paolo Grieco and Dr. Maria Patrizia Stoppelli
Article first published online: 20 MAR 2013 | DOI: 10.1002/cbic.201200774
One peptide, two signals: This study revealed two adjacent regions in urokinase conveying opposite signalling on cell migration. Secondary structure elements characterise either the inhibitory or the stimulatory peptide groups. This knowledge might aid the design of novel inhibitory peptides or peptidomimetics of pathological cell migration and invasion.