Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient (pages 1105–1115)
Dr. Flaviana Di Lorenzo, Dr. Luisa Sturiale, Dr. Angelo Palmigiano, Dr. Luigi Lembo- Fazio, Dr. Ida Paciello, Dr. Carla P. Coutinho, Prof. Isabel Sá-Correia, Prof. MariaLina Bernardini, Prof. Rosa Lanzetta, Dr. Domenico Garozzo, Dr. Alba Silipo and Prof. Antonio Molinaro
Article first published online: 3 JUN 2013 | DOI: 10.1002/cbic.201300062
Listening to the patient: The elucidation of the structure of the lipooligosaccharide from Burkholderia dolosa, isolated from a cystic fibrosis patient, is essential to understand biological structure–activity relationships. Such data are instrumental in aiding the design of antimicrobial compounds and for the development of therapeutic strategies against the inflammatory cascade.