DNA-Scaffolded Multivalent Ligands to Modulate Cell Function (pages 1268–1273)
Prof. Dr. Zhiqing Zhang, Dr. Mark A. Eckert, Dr. M. Monsur Ali, Linan Liu, Dr. Dong-Ku Kang, Elizabeth Chang, Dr. Egest J. Pone, Prof. Dr. Leonard S. Sender, Prof. Dr. David A. Fruman and Prof. Dr. Weian Zhao
Version of Record online: 6 MAY 2014 | DOI: 10.1002/cbic.201402100
On a roll: DNA molecules synthesized by rolling-circle amplification can serve as simple polymeric scaffolds to interrogate and modulate cell-receptor functions. We have demonstrated that our multivalent ligand can induce apoptosis of cancer cells more effectively than its monovalent counterpart; this represents a new approach for the development of therapeutics.