Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster (pages 2189–2198)
Anyarat Thanapipatsiri, Dr. Juan Pablo Gomez-Escribano, Dr. Lijiang Song, Maureen J. Bibb, Dr. Mahmoud Al-Bassam, Dr. Govind Chandra, Prof. Arinthip Thamchaipenet, Prof. Gregory L. Challis and Prof. Mervyn J. Bibb
Version of Record online: 13 OCT 2016 | DOI: 10.1002/cbic.201600396
Transcriptional profiling of a bldM developmental mutant of Streptomyces venezuelae revealed the activation of transcription of a cryptic gene cluster encoding an unusual biaryl polyketide (venemycin) and halogenated derivatives. Production of the compounds was also elicited by introducing the gene cluster into the heterologous host Streptomyces coelicolor combined with constitutive expression of the cluster-situated regulatory gene venR.