Polyglycine II Nanosheets: Supramolecular Antivirals? (pages 147–154)
Alexander B. Tuzikov, Alexander A. Chinarev, Alexandra S. Gambaryan, Vladimir A. Oleinikov, Dmitry V. Klinov, Nadezhda B. Matsko, Vasily A. Kadykov, Mikhail A. Ermishov, Il'ya V. Demin, Victor V. Demin, Phil D. Rye and Nicolai V. Bovin
Article first published online: 27 FEB 2003 | DOI: 10.1002/cbic.200390025
Wrapping up against a cold: Self-assembly of tetraantennary peptides [glycinen-NHCH2]4C through intermolecular hydrogen bonding leads to the formation of stable noncovalent polyglycine-II-type structures in water. These submicron-sized structures consist of one-molecule-thick flat sheets (see figure). The attachment of α-N-acetylneuraminic acid to the terminal glycine residues gives rise to water-soluble self-assembled glycopeptide sheets that are able to bind and inhibit the influenza virus at concentrations of 10−7–10−8 M.