A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IκBα Phosphorylation (pages 133–144)
Ta-Hsiang Chao, Thanh Lam, Binh G. Vong, Paqui G. Través, Sonsoles Hortelano, Chinmay Chowdhury, F. Rena Bahjat, G. Kenneth Lloyd, Lyle L. Moldawer, Lisardo Boscá, Michael A. Palladino and Emmanuel A. Theodorakis
Version of Record online: 12 NOV 2004 | DOI: 10.1002/cbic.200400089
Not all puffed up. The privileged structure of acanthoic acid (1) led to the synthesis of a new family of synthetic diterpenes, represented by motif 2, that have potent anti-inflammatory activities. The mode of action of these compounds may involve inhibition of IκBα phosphorylation, thereby regulating the NF-κB-mediated synthesis of certain proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6.