PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a New Mitochondrial Benzodiazepine-Receptor Ligand, Induces Apoptosis in C6 glioma Cells (pages 1082–1088)
Beatrice Chelli, Leonardo Rossi, Eleonora Da Pozzo, Barbara Costa, Francesca Spinetti, Mariarosa Rechichi, Alessandra Salvetti, Annalisa Lena, Francesca Simorini, Renato Vanacore, Fabrizio Scatena, Federico Da Settimo, Vittorio Gremigni and Claudia Martini
Version of Record online: 10 MAY 2005 | DOI: 10.1002/cbic.200400350
Therapeutic potential against glial tumours. The selective mBzR ligand PIGA induced apoptosis in rat C6 glioma cells, dissipated mitochondrial transmembrane potential and caused cytosolic accumulation of cytochrome c. Characteristic features of apoptotic cell death, such as caspase-3 activation and DNA fragmentation, were detected in PIGA-treated cells.