A Small-Molecule Antagonist of the Hedgehog Signaling Pathway (pages 1916–1919)
Jongkook Lee, Xu Wu, Marina Pasca di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y. Cho and Peter G. Schultz
Version of Record online: 20 SEP 2007 | DOI: 10.1002/cbic.200700403
Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.