Long-term muscle-derived cell culture: multipotency and susceptibility to cell death stimuli
Article first published online: 29 JAN 2013
© 2013 International Federation for Cell Biology
Cell Biology International
Volume 37, Issue 4, pages 292–304, April 2013
How to Cite
Kalvelyte, A., Krestnikova, N., Stulpinas, A., Bukelskiene, V., Bironaite, D., Baltriukiene, D. and Imbrasaite, A. (2013), Long-term muscle-derived cell culture: multipotency and susceptibility to cell death stimuli. Cell Biology International, 37: 292–304. doi: 10.1002/cbin.10036
- Issue published online: 11 MAR 2013
- Article first published online: 29 JAN 2013
- Accepted manuscript online: 4 JAN 2013 04:39AM EST
- Manuscript Accepted: 3 DEC 2012
- Manuscript Received: 4 OCT 2012
- cell death;
- muscle-derived stem cell lines
Improvement in the yield of adult organism stem cells, and the ability to manage their differentiation and survival potential are the major goals in their application in regenerative medicine and in the adult stem cell research. We have demonstrated that adult rabbit muscle-derived cell lines with an unlimited proliferative potential in vitro can differentiate into myogenic, osteogenic, adipogenic and neurogenic lineages. Studies of cell survival in vitro showed that differentiated cells, except neurogenic ones, are more resistant to apoptosis inducers compared to proliferating cells. Resistance to death signals correlated with the level of protein kinase AKT phosphorylation. Skeletal muscle-derived cell lines can be multipurpose tools in therapy. Enhanced resistance of differentiated cells to certain types of damage shows their potential for long-term survival and maintenance in an organism.
This article was published online on 29 January 2013. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 6 March 2013.