Get access

Vinculin, cell mechanics and tumour cell invasion

Authors

  • Wolfgang H. Goldmann,

    Corresponding author
    • Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany
    Search for more papers by this author
  • Vera Auernheimer,

    1. Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany
    Search for more papers by this author
  • Ingo Thievessen,

    1. Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany
    Search for more papers by this author
  • Ben Fabry

    1. Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany
    Search for more papers by this author

Corresponding author: e-mail: wgoldmann@biomed.uni-erlangen.de

Abstract

The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.

Ancillary