Stem cells conditioned medium: a new approach to skin wound healing management

Authors

  • Pukana Jayaraman,

    1. Department of Children‘s Dentistry and Orthodontics, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
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  • Prakash Nathan,

    1. Hygieia Innovation Sdn Bhd (852106-M), Lot 1G-2G, Lanai Complex No. 2, Persiaran Seri Perdana, Precint 10, Federal Territory of Putrajaya, Malaysia
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  • Punitha Vasanthan,

    1. Department of Children‘s Dentistry and Orthodontics, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
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  • Sabri Musa,

    Corresponding author
    • Department of Children‘s Dentistry and Orthodontics, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
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  • Vijayendran Govindasamy

    1. Hygieia Innovation Sdn Bhd (852106-M), Lot 1G-2G, Lanai Complex No. 2, Persiaran Seri Perdana, Precint 10, Federal Territory of Putrajaya, Malaysia
    2. KOZA Sdn Bhd (947767-T), 13.3A, Menara 1 Mont Kiara, Jalan Kiara, 50480 Mont Kiara, Kuala Lumpur, Malaysia
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Corresponding author: e-mail: sabrim@um.edu.my (S. Musa); vijay@hygieiagroup.com (V. Govindasamy)

Abstract

Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine. Initially upon transplantation, these cells home to and differentiate within the injured tissue into specialised cells. Contrariwise, it now appears that only a small percentage of transplanted cells integrate and survive in host tissues. Thus, the foremost mechanism by which stem cells participate in tissue repair seems to be related to their trophic factors. Indeed, stem cells provide the microenvironment with a wide range of growth factors, cytokines and chemokines, which can broadly defined as the stem cells secretome. In in vitro condition, these molecules can be traced from the conditioned medium or spent media harvested from cultured cells. Conditioned medium now serves as a new treatment modality in regenerative medicine and has shown a successful outcome in some diseases. With the emergence of this approach, we described the possibility of using stem cells conditioned medium as a novel and promising alternative to skin wound healing treatment. Numerous pre-clinical data have shown the possibility and efficacy of this treatment. Despite this, significant challenges need to be addressed before translating this technology to the bedside.

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