These authors contributed equally to the article.
Expansion of the polyQ repeats in THAP11 forms intranuclear aggregation and causes cell G0/G1 arrest
Article first published online: 20 FEB 2014
© 2014 International Federation for Cell Biology
Cell Biology International
Volume 38, Issue 6, pages 757–767, June 2014
How to Cite
Yin, R.-H., Li, Y., Yang, F., Zhan, Y.-Q., Yu, M., Ge, C.-H., Xu, W.-X., Tang, L.-J., Wang, X.-H., Chen, B., Yang, Y., Li, J.-J., Li, C.-Y. and Yang, X.-M. (2014), Expansion of the polyQ repeats in THAP11 forms intranuclear aggregation and causes cell G0/G1 arrest. Cell Biology International, 38: 757–767. doi: 10.1002/cbin.10255
- Issue published online: 8 MAY 2014
- Article first published online: 20 FEB 2014
- Accepted manuscript online: 6 FEB 2014 06:18AM EST
- Manuscript Accepted: 27 JAN 2014
- Manuscript Received: 20 AUG 2013
- Chinese National Natural Science Foundation project. Grant Numbers: 81222005, 30480659
- Major State Basic Research of China. Grant Number: 2010CB911904
- Beijing National Natural Science Foundation project. Grant Number: 7071007
Additional supporting information may be found in the online version of this article at the publisher's web-site
Figure S1. Distribution of the CAG repeat length at THAP11 locus in normal individuals and spinocerebellar ataxias patients in the Chinese Han population. n refers to the number of chromosomes.
Figure S2. Stable PC12 cell line expressing pVg-RXR was transfected with pIND- THAP11(29Q) or pIND-THAP11(38Q) vector and then the cells were treated with 5μM PonA for the indicated time. Cells were harvested and the expression of THAP11 were detected by Western Blotting analysis using anti-THAP11 antibody. β-actin was used as an internal control. exTHAP11: exogenous THAP11; enTHAP11: endogenous THAP11.
Figure S3. Identification of THAP11 binding proteins in PC12 cells.
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