SEARCH

SEARCH BY CITATION

Keywords:

  • autoregulatory network;
  • breast cancer metastasis;
  • cancer stem cell;
  • epithelial to mesenchymal transition;
  • transforming growth factor-beta

Abstract

Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.