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The perivascular niche governs an autoregulatory network to support breast cancer metastasis

Authors

  • Hassan Fazilaty,

    1. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
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  • Babak Behnam

    Corresponding author
    1. Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
    2. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
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Abstract

Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.

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