Mesenchymal stem cell based therapy for osteo-diseases

Authors

  • Mohammad Mousaei Ghasroldasht,

    1. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    2. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
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  • Muhammad Irfan-Maqsood,

    1. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    2. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
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  • Maryam M. Matin,

    1. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    2. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
    3. Cell and Molecular Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
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  • Hamid Reza Bidkhori,

    1. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
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  • Hojjat Naderi-Meshkin,

    1. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
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  • Ali Moradi,

    1. Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
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  • Ahmad Reza Bahrami

    Corresponding author
    1. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    2. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran
    3. Cell and Molecular Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
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Abstract

Stem cell therapy in recent years has gained much attention as the modern therapeutic approach to treat diseases. Mesenchymal stem cells (MSCs) are seen as the most reliable cells applied in therapy over other stem cells because of their versatility. Bone and cartilage diseases (osteo-diseases) are the major target of therapy using MSCs. In this perspective, we have statistically analyzed the data available on clinical trials registry databases regarding the mesenchymal stem cell based therapy for a number of mentioned diseases and paid attention towards the osteodiseases. We report that MSC therapy for osteo-diseases needs optimization in its standards to achieve acceptable results so that we can apply it in daily routine clinical practice.

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