These authors contributed equally to this work.
Coating of electrospun poly(lactic-co-glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model
Article first published online: 6 JUN 2014
© 2014 International Federation for Cell Biology
Cell Biology International
Volume 38, Issue 11, pages 1271–1279, November 2014
How to Cite
Jamshidi Adegani, F., Langroudi, L., Ardeshirylajimi, A., Dinarvand, P., Dodel, M., Doostmohammadi, A., Rahimian, A., Zohrabi, P., Seyedjafari, E. and Soleimani, M. (2014), Coating of electrospun poly(lactic-co-glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model. Cell Biology International, 38: 1271–1279. doi: 10.1002/cbin.10318
- Issue published online: 6 OCT 2014
- Article first published online: 6 JUN 2014
- Accepted manuscript online: 6 JUN 2014 04:17AM EST
- Manuscript Accepted: 6 MAY 2014
- Manuscript Received: 2 FEB 2014
- calvarial defects;
- tissue engineering;
We have investigated the combination effects of bioceramics and poly(lactide-co-glycolide) (PLGA) on bone reconstruction in calvarial critical size defects using a rat model. Willemite (Zn2SiO4) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral-computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite-coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.