Conflict of interest: Nothing to report.
Coronary Artery Disease
Comparison of in vivo eccentricity and symmetry indices between metallic stents and bioresorbable vascular scaffolds: Insights from the ABSORB and SPIRIT trials†
Article first published online: 11 MAY 2011
Copyright © 2011 Wiley Periodicals, Inc.
Catheterization and Cardiovascular Interventions
Volume 79, Issue 2, pages 219–228, 1 February 2012
How to Cite
Brugaletta, S., Gomez-Lara, J., Diletti, R., Farooq, V., Jan van Geuns, R., de Bruyne, B., Dudek, D., Garcia-Garcia, H. M., Ormiston, J. A. and Serruys, P. W. (2012), Comparison of in vivo eccentricity and symmetry indices between metallic stents and bioresorbable vascular scaffolds: Insights from the ABSORB and SPIRIT trials. Cathet. Cardiovasc. Intervent., 79: 219–228. doi: 10.1002/ccd.22996
- Issue published online: 23 JAN 2012
- Article first published online: 11 MAY 2011
- Manuscript Accepted: 16 JAN 2011
- Manuscript Received: 10 JAN 2011
- XIENCE V
Objective: To compare the geometrical parameters of a bioresorbable vascular scaffold (BVS) with a standard metallic stent. Background: The introduction of polymeric bioresorbable materials in the design of novel coronary scaffolds may affect some geometrical parameters, such as eccentricity and symmetry indices, previously introduced as IVUS criteria for optimal metallic stent deployment. Methods: From ABSORB Cohort A, ABSORB Cohort B, SPIRIT I, and SPIRIT II, all patients implanted with BVS 1.0, BVS 1.1, or XIENCE V, respectively and intravascular ultrasound analyses post-implantation were selected. The eccentricity index was calculated frame by frame and expressed as an average per device (minimum diameter/maximum diameter). The symmetry index of the device was reported as ([maximum diameter − minimum diameter]/maximum diameter).Six months major adverse cardiac events (MACE) were analyzed. Results: A total of 242 patients were selected (BVS 1.0: n = 28, BVS 1.1: n = 94, XIENCE V: n = 120). The BVS exhibited a significantly lower eccentricity index (BVS 1.0: 0.83 ± 0.09; BVS 1.1: 0.85 ± 0.08; XIENCE V: 0.90 ± 0.06; P < 0.01) and a significantly higher symmetry index (BVS 1.0: 0.30 ± 0.07; BVS 1.1: 0.31 ± 0.06, XIENCE V 0.26 ± 0.07; P < 0.01) as compared to the XIENCE V. An inverse correlation was found between the symmetry and eccentricity indices for both (BVS r = −0.69, P < 0.01; XIENCE V r = −0.61, P < 0.01). No differences in MACE were detected between the groups according to their geometrical parameters. Conclusions: The introduction of a new polymeric material in the design of BVS resulted in a lower eccentricity index and a higher symmetry index as compared to metallic stents, without detectable impact in MACE, at 6 months. © 2011 Wiley Periodicals, Inc.