Conflict of interest: Nothing to report.
Coronary Artery Disease
Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)†
Rationale and Design
Article first published online: 5 OCT 2011
Copyright © 2011 Wiley-Liss, Inc.
Catheterization and Cardiovascular Interventions
Volume 79, Issue 6, pages 967–971, 1 May 2012
How to Cite
Liu, P., Jiang, J., Li, J., Hong, T., Zhang, Y., Yu, R., Jia, J. and Huo, Y. (2012), Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study). Cathet. Cardiovasc. Intervent., 79: 967–971. doi: 10.1002/ccd.23171
- Issue published online: 17 APR 2012
- Article first published online: 5 OCT 2011
- Manuscript Accepted: 19 MAR 2011
- Manuscript Received: 6 JAN 2011
- China Medical Foundation
- percutaneous coronary intervention;
- myocardial infarction;
Background: Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow-up. Statins have been demonstrated to lower the risk of periprocedural myocardial infarction. The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long-term outcome of patients in the Asian population. Study design: Approximately 1,100 patients with stable angina or non-ST elevation acute coronary syndrome undergoing selective percutaneous coronary intervention (PCI) are enrolled in this study. Patients are randomized either to the experimental group (80 mg atorvastatin 80 mg/day × 2 days before and 40 mg/day × 30 days after PCI) or to the control group (usual care). Creatine kinase-MB (CK-MB), troponin I (cTnI), and serum creatine are measured at 24 hours after the procedure. The total follow-up period is 6 months. The primary objective is to evaluate the efficacy of intensive atorvastatin treatment compared with usual care in reducing 30-day primary cardiovascular endpoints in patients undergoing selective PCI. Secondary endpoints are changes in myocardial biomarkers (cTnI, CK-MB) and hs-CRP, CIN morbidity, 6-month clinical outcomes, and safety. Conclusion: The result of the ISCAP study will provide important evidence on the efficacy and safety of periprocedural serial intensive statin treatment in Asian patients with coronary artery disease undergoing selective PCI. © 2011 Wiley Periodicals, Inc.