Conflict of interest: Nothing to report
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Coronary Artery Disease
Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus†
Article first published online: 8 DEC 2011
DOI: 10.1002/ccd.23184
Copyright © 2011 Wiley Periodicals, Inc.
Additional Information
How to Cite
Gunn, J., Siotia, A., Malkin, C. J., Iqbal, J., Raina, T. and Morton, A. C. (2012), Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus. Cathet. Cardiovasc. Intervent., 80: 59–64. doi: 10.1002/ccd.23184
- †
Publication History
- Issue published online: 26 JUN 2012
- Article first published online: 8 DEC 2011
- Manuscript Accepted: 27 MAR 2011
- Manuscript Received: 18 JAN 2011
Funded by
- Cardiovascular Biomedical Research Unit sponsored part of Dr. Morton's salary
- Abstract
- Article
- References
- Cited By
Keywords:
- coronary thrombosis;
- stent graft;
- percutaneous coronary intervention
Abstract
Objectives: We studied the acute safety and feasibility of a pericardium-covered stent (PCS) in the obliteration of massive coronary thrombus. Background: Thrombus is frequently encountered in the setting of acute myocardial infarction, and conventional pharmacological and aspiration approaches are not always successful in dispersing or removing it, especially when it is very substantial. Methods: We treated nine patients (10 lesions) in the setting of an acute coronary syndrome characterized by the presence of substantial (TIMI grade 3–4) thrombus in a large caliber native coronary artery, persisting after conventional treatment, with percutaneous implantation of an equine PCS graft. Nine of 10 lesions were in large right coronary arteries. Results: Deployment was successful in nine of 10 lesions. In all nine cases, the filling defect was immediately eliminated and there was restoration or maintenance of TIMI grade 3 blood flow. There was one in-hospital stent thrombosis in a 56-year-old male, who had only received aspirin due to a coexistent stroke. This patient underwent successful repeat percutaneous intervention but died later of complications of the stroke. There were no 30-day events, and medium-term follow-up continues. Conclusions: A PCS graft is a potentially useful device to treat massive thrombus burden in the setting of acute coronary syndrome. A larger study is warranted. © 2011 Wiley Periodicals, Inc.