Xing-Sheng Yang and Hua-Gang Zhu contributed equally to this work.
Coronary Artery Disease
The union of Anti-CD34 antibody can improve the performance of drug-eluting stents†
Version of Record online: 8 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
Catheterization and Cardiovascular Interventions
Volume 79, Issue 6, pages 972–978, 1 May 2012
How to Cite
Yang, X.-S., Zhu, H.-G., Yu, Z.-J., Ren, F., Chen, Y.-Q., Wu, X., Zhang, Z.-C., Zhang, L.-J. and Lu, S.-Z. (2012), The union of Anti-CD34 antibody can improve the performance of drug-eluting stents. Cathet. Cardiovasc. Intervent., 79: 972–978. doi: 10.1002/ccd.23186
Conflict of interest: Nothing to report
- Issue online: 17 APR 2012
- Version of Record online: 8 DEC 2011
- Manuscript Accepted: 26 MAR 2011
- Manuscript Received: 7 FEB 2011
- National Natural Science Foundation of China. Grant Number: 30770581
- Beijing Municipal Science & Technology Commission, China. Grant Number: D0906006000091
- anti-CD34 antibody;
- drug-eluting stents;
- endothelial progenitor cells;
- optical coherence tomography
Objectives: The authors investigate whether the combination of anti-CD34 antibody with DES is win–win cooperation. Background: DES may reduce the risk of restenosis compared to bare-metal stents (BMS), but they were found to inhibit the healing process of intima. Methods: Fifteen BMS, 17 DES, and 16 combined anti-CD34 antibody and DES were randomly implanted in the coronary arteries of 22 minipigs. Ten minipigs were followed up to 2 weeks. The stenting coronary segments were examined by histological examination and scanning electron microscopy after in vivo coronary angiography and intracoronary optical coherence tomography (OCT) examinations. The other 12 minipigs were followed up to 3 months. Coronary angiography and intracoronary OCT examination were performed in vivo and histological examination was performed on the stenting coronary segments. Results: After 2 weeks, the neointimal covering level of the DES was lower than that in BMS, but the covering level of the combined stents was even better than the BMS. After 3 months, neointimal hyperplasia was significant in the BMS, but not in the other two types of stents. The in-stent late lumen loss of the combined stents even showed a decreasing tendency when compared with the DES. Conclusion: The combination of anti-CD34 antibody and DES can not only well offset the short-term inhibitory effect on re-endothelialization but also slightly enhance the long-term antiproliferative effect. © 2011 Wiley Periodicals, Inc.