Three-dimensional imaging of fibrous cap by frequency-domain optical coherence tomography

Authors

  • Hiram G. Bezerra MD, PhD,

    1. Harrington-McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
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  • Guilherme F. Attizzani MD,

    1. Harrington-McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
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  • Marco A. Costa MD, PhD

    Corresponding author
    • Harrington-McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
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  • Conflict of interest: Hiram Bezerra receives honoraria and research grants from St Jude Medical Inc.; Marco Costa receives honoraria and research grants from St Jude Medical Inc.; Guilherme Attizzani does not have any conflicts of interest to declare.

Correspondence to: Marco A. Costa, MD, PhD, Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, 11100 Euclid Avenue Cleveland, OH 44106. E-mail: marco.costa@uhhospitals.org

Abstract

Histopathological data correlated the presence of thin-cap fibroatheroma (TCFA) with adverse cardiovascular events. Intravascular optical coherence tomography (iOCT) is currently the only imaging modality with sufficiently high axial resolution (∼15 μm) that allows direct fibrous-cap (FC) assessment in vivo. iOCT quantification of TCFA has been validated, but the assessment of a single cross-sectional image does not depict the complexity of the atherosclerotic plaque. We present two cases that illustrate the importance of three-dimensional volumetric quantification of the FC capitalizing on the properties of frequency-domain iOCT. © 2012 Wiley Periodicals, Inc.

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