Jung Ho Heo and Salvatore Brugaletta have equally contributed to this manuscript.
E-ONLY: Coronary Artery Disease
Reproducibility of intravascular ultrasound iMAP for radiofrequency data analysis: Implications for design of longitudinal studies
Article first published online: 30 NOV 2013
Copyright © 2011 Wiley Periodicals, Inc., a Wiley company
Catheterization and Cardiovascular Interventions
Volume 83, Issue 7, pages E233–E242, 1 June 2014
How to Cite
Heo, J. H., Brugaletta, S., Garcia-Garcia, H. M., Gomez-Lara, J., Ligthart, J. M.R., Witberg, K., Magro, M., Shin, E.-S. and Serruys, P. W. (2014), Reproducibility of intravascular ultrasound iMAP for radiofrequency data analysis: Implications for design of longitudinal studies. Cathet. Cardiovasc. Intervent., 83: E233–E242. doi: 10.1002/ccd.23335
Conflict of interest: nothing to report.
- Issue published online: 17 MAY 2014
- Article first published online: 30 NOV 2013
- Accepted manuscript online: 22 NOV 2011 02:18PM EST
- Manuscript Accepted: 8 AUG 2011
- Manuscript Revised: 4 JUL 2011
- Manuscript Received: 15 MAR 2011
- intravascular ultrasound;
Background: iMAP is a new intravascular ultrasound (IVUS) derived technique for tissue characterization using spectral analysis. Since there is a need for reproducibility data to design longitudinal studies, we sought to assess the in vivo reproducibility of this imaging technique. Methods: iMAP (40 MHz, Boston Scientific Corporation) was performed in patients referred for elective percutaneous intervention and in whom a nonintervened vessel was judged suitable for a safe IVUS analysis. Overall 20 patients with 20 non-angiographically significant lesions were assessed by two independent observers. Five of these 20 patients received an additional iMAP analysis using a new IVUS catheter and using the same catheter after its engagement and reengagement. Results: The interobserver relative difference in plaque area was 2.5%. Limits of agreement for lumen, vessel, and plaque area measurements were 1.62, −2.47 mm2; 2.09, −3.71 mm2; 2.80, −3.72 mm2; respectively. Limits of agreement for fibrotic, lipidic, necrotic, and calcified measurements were 1.32, −1.44 mm2; 0.24, −0.36 mm2; 1.50, −2.26 mm2; 0.09, −0.11 mm2; respectively. The intercatheter and intracatheter relative difference in plaque area were 0.9% and 4.1%, respectively. Although the variability for compositional measurements increased using two different catheters or using the same catheter twice, the variability for compositional measurements keeps always below 10%. Conclusions: Our analysis demonstrates that the geometrical and compositional iMAP analysis is acceptably reproducible. © 2011 Wiley Periodicals, Inc.