VIABAHN® endoprosthesis (Gore & Associates, Flagstaff, AZ), a nitinol self-expanding polytetrafluoroethylene (PTFE) lined stent, has demonstrated utility for percutaneous treatment of chronic occlusive disease involving the superficial femoral artery. In a case series communication we aimed to describe the feasibility of a PTFE-lined stent for percutaneous treatment of conditions other than chronic occlusive disease. We report the successful use of PTFE-endoprosthesis to percutaneously treat several vascular conditions, including arterio–venous fistula closure, reconstruction of a distal limb of an aorto–femoral endoprosthesis aneurysm, femoral artery perforation repair, and an exclusion of large saphenous vein graft aorto–coronary bypass aneurysm. This case series illustrates the feasibility of the “off-label” use of self-expanded PTFE endoprosthesis to percutaneously treat several conditions, which would otherwise require “open” surgical reconstructions. © 2011 Wiley Periodicals, Inc.