Conflict of interest: Nothing to report.
Coronary Artery Disease
Safety and efficacy of everolimus-eluting stents versus paclitaxel-eluting stents in a diabetic population
Article first published online: 23 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Catheterization and Cardiovascular Interventions
Volume 81, Issue 5, pages 759–765, April 2013
How to Cite
Laynez, A., Sardi, G., Hauville, C., Barbash, I. M., Pakala, R., Torguson, R., Xue, Z., Satler, L. F., Pichard, A. D. and Waksman, R. (2013), Safety and efficacy of everolimus-eluting stents versus paclitaxel-eluting stents in a diabetic population. Cathet. Cardiovasc. Intervent., 81: 759–765. doi: 10.1002/ccd.24438
- Issue published online: 21 MAR 2013
- Article first published online: 23 APR 2012
- Accepted manuscript online: 4 APR 2012 06:17AM EST
- Manuscript Accepted: 27 MAR 2012
- Manuscript Revised: 1 MAR 2012
- Manuscript Received: 6 DEC 2011
- Everolimus-eluting stent;
- Paclitaxel-eluting stent;
This study aimed to analyze the use of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in an unrestricted diabetic population and to compare the performance of these two drug-eluting stents.
EES have demonstrated superiority in efficacy when compared to PES in a general population. However, it is controversial whether this superiority holds true in a diabetic population.
From March 2004 to May 2010, 968 patients with consecutive diabetes who underwent percutaneous coronary intervention and implantation of an EES (n = 388) or PES (n = 580) at our institution. In-hospital, 1-month, 6-month, and 1-year clinical outcomes were analyzed and compared. Correlates of major adverse cardiac events (MACE) were identified.
Baseline clinical characteristics were similar between stent types except for more family history of coronary artery disease in the PES group and more insulin-dependent diabetes and unstable angina at initial diagnosis in the EES group. The PES group had higher number of lesions treated, longer stents used, and a higher proportion of intravascular ultrasound and glycoprotein IIb/IIIa inhibitor use. The EES group had more type C and distal lesions. There was higher target lesion revascularization (TLR)-MACE in the PES group (3.3% vs. 1.0%, P = 0.03) as well as a higher rate of stent thrombosis (ST) (8 patients vs. 0 in the EES group, P = 0.03). ST continued to be higher in the PES group at 6 and 12 months and mortality was higher at 12 months in the PES group (9.4% vs. 5.2%, P = 0.02). After adjustment, no significant differences were found between stent types on Cox regression analysis for hazard ratios at 1-year follow-up of TLR-MACE.
In a diabetic population undergoing PCI, the use of an EES compared to PES was associated with lower rates of stent thrombosis; but after adjustment the composite TLR-MACE at 1 year was similar between both stents. © 2012 Wiley Periodicals, Inc.