Disclosures: All authors have made important contributions to the study and are thoroughly familiar with the primary data.
Coronary Artery Disease
One-year outcomes of consecutive patients treated by endeavor zotarolimus and resolute zotarolimus stents: The impact of polymer coating in drug-eluting stent technology
Article first published online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Catheterization and Cardiovascular Interventions
Volume 81, Issue 2, pages 268–273, February 2013
How to Cite
Talarico, G. P., Burzotta, F., Trani, C., Tommasino, A., Niccoli, G., Porto, I., Leone, A. M., Mongiardo, R., Schiavoni, G. and Crea, F. (2013), One-year outcomes of consecutive patients treated by endeavor zotarolimus and resolute zotarolimus stents: The impact of polymer coating in drug-eluting stent technology. Cathet. Cardiovasc. Intervent., 81: 268–273. doi: 10.1002/ccd.24498
Conflict of interest: Francesco Burzotta and Antonella Tommasino report their involvement in an expert advisory board of Medtronic.
- Issue published online: 19 FEB 2013
- Article first published online: 14 NOV 2012
- Accepted manuscript online: 28 MAY 2012 04:31AM EST
- Manuscript Accepted: 20 MAY 2012
- Manuscript Received: 5 SEP 2011
- percutaneous coronary interventions;
- zotarolimus eluting-stent
Polymer-coating represents a key component of drug-eluting stent (DES) technology and its possible impact on vessel-wall healing is a matter of debate. The clinical impact of different polymer-coating may be assessed by comparing the outcome of patients treated by DES having the same stent platform and drug, and differing in the polymer. Thus, we compared the clinical outcome of patients treated by Endeavor Zotarolimus-eluting stent (E-ZES) and Resolute Zotarolimus-eluting stent (R-ZES) as they differ in the polymer-coating only.
At our Institution, E-ZES was available during a first period and then it was substituted by the R-ZES during a second period. Clinical, angiographic, and procedural data were prospectively collected. Clinical follow-up was prospectively obtained up to 1-year. Primary endpoint was the occurrence of major adverse cardiac events (MACE) at 12-month.
A total of 467 patients undergoing percutaneous coronary intervention were enrolled: 233 patients treated with E-ZES and 234 with R-ZES. Patients treated by R-ZES had similar clinical characteristics and worse angiographic characteristics compared with those treated by E-ZES. At 12-month follow-up, MACE rate was significantly lower in the R-ZES group compared with E-ZES group (4.2% vs. 14.6%; P < 0.01). This difference was due to nonsignificantly lower rates of death and myocardial infarction and to significant lower rate of target-lesion-revascularization (R-ZES 3.4% vs. E-ZES 10.3%, P < 0.01).
The results of this study suggest that the clinical outcome of patients treated by DES differing for the polymer coating only may be different. Polymer coating is a pivotal, probably underrated, component of DES technology which may influence the clinical performance of DES. © 2012 Wiley Periodicals, Inc.