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Resolute® and xience V® polymer-based drug-eluting stents compared in an atherosclerotic rabbit double injury model

Authors

  • Christophe J. Van Dyck MSc,

    1. Department of Cardiology, Laboratory for Cellular and Molecular Cardiology, Antwerp University Hospital, Antwerp, Belgium
    2. Department of Translational Pathophysiological Research, Laboratory of Cardiology, University of Antwerp, Antwerp, Belgium
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  • Vicky Y. Hoymans PhD,

    1. Department of Cardiology, Laboratory for Cellular and Molecular Cardiology, Antwerp University Hospital, Antwerp, Belgium
    2. Department of Translational Pathophysiological Research, Laboratory of Cardiology, University of Antwerp, Antwerp, Belgium
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  • Hidde Bult PhD,

    1. Department of Translational Pathophysiological Research, Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
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  • Erik Fransen PhD,

    1. StatUa Center for Statistics, University of Antwerp, Antwerp, Belgium
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  • Steven Haine MD,

    1. Department of Cardiology, Laboratory for Cellular and Molecular Cardiology, Antwerp University Hospital, Antwerp, Belgium
    2. Department of Translational Pathophysiological Research, Laboratory of Cardiology, University of Antwerp, Antwerp, Belgium
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  • Johan M. Bosmans MD PhD,

    1. Department of Cardiology, Laboratory for Cellular and Molecular Cardiology, Antwerp University Hospital, Antwerp, Belgium
    2. Department of Translational Pathophysiological Research, Laboratory of Cardiology, University of Antwerp, Antwerp, Belgium
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  • Jean-Pierre Timmermans PhD,

    1. Department of Veterinary Sciences, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium
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  • Christiaan J. Vrints MD PhD

    Corresponding author
    1. Department of Translational Pathophysiological Research, Laboratory of Cardiology, University of Antwerp, Antwerp, Belgium
    • Department of Cardiology, Laboratory for Cellular and Molecular Cardiology, Antwerp University Hospital, Antwerp, Belgium
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  • Conflict of interest: Nothing to report.

Correspondence to: Prof Dr Christiaan J. Vrints, MD PhD, Antwerp University Hospital, Department of Cardiology, Wilrijkstraat 10, 2650 Antwerp, Belgium. E-mail: chris.vrints@uza.be

Abstract

Aim

To evaluate differences in strut coverage, inflammation and endothelialization between two second-generation polymer-based drug-eluting stents (DES) in an atherosclerotic rabbit double-injury iliac artery model at 28 days follow-up. Methods and results: Rabbits with induced atheroma received bilateral iliac artery stents: everolimus-eluting stent (Xience V EES; Abbott Vascular), zotarolimus-eluting stent (Resolute ZES; Medtronic CardioVascular), or bare-metal stent (BMS; MultiLink Vision; Abbott Vascular). After 28 days, total neointimal coverage examined by scanning electron microscopy was >98% for all three stent types. Neointimal thickness above stent struts was decreased by 50% in Xience V EES (0.06 ± 0.01 mm; P = 0.00001) compared with BMS (0.15 ± 0.03 mm) and Resolute ZES (0.12 ± 0.04 mm). Luminal area was largest for Xience V EES (3.79 ± 0.33 mm2; P = 0.0003 for Xience V EES vs. BMS), followed by Resolute ZES (3.46 ± 0.45 mm2; P = 0.083 for Resolute ZES vs. BMS) and BMS (3.07 ± 0.53 mm2). Percentage area stenosis was smallest for Xience V EES (17.23 ± 3.64%; P = 0.00001), while BMS (30.25 ± 7.48%) and Resolute ZES (30.79 ± 7.15%) did not differ. Endothelial monolayer regrowth was significantly lower in Resolute ZES (65 ± 13%) versus BMS (79 ± 11%; P = 0.004). There was no difference between Xience V EES (74 ± 10%) and BMS. Xience V EES was further associated with a lower number of inflammatory cells surrounding the stent struts (7 ± 2 per strut) in comparison to Resolute ZES (15 ± 6; P = 0.0001) and BMS (17 ± 9; P = 0.0005).

Conclusion

In this atherosclerotic rabbit model, Xience V EES suppressed neointimal thickening better, with normal endothelial regrowth as compared with BMS, and less strut-induced inflammation. © 2012 Wiley Periodicals, Inc.

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