Porcine model of intracoronary pulverization of stent struts by rotablation atherectomy

Authors

  • Thuy Tran Quang MD, PhD,

    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Raja Hatem MD,

    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Guy Rousseau PhD,

    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    2. Département de Pharmacologie, Université de Montréal, Montréal, Québec, Canada
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  • Bruno Dube MS,

    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Caroline Samson MD,

    1. Département de Radiographie, Hôpital de Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Erick Schampaert MD,

    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    2. Département de Cardiologie, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Thierry Charron MD

    Corresponding author
    1. Centre de Recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    2. Département de Cardiologie, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    • Correspondence to: Dr. Thierry Charron, M.D., 5400, Boul. Gouin Ouest, Montréal, Québec H4J 1C5, Canada. E-mail: charront01@sympatico.ca

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  • Conflict of interest: Nothing to report.

Abstract

Objective

To evaluate the feasibility and safety of rotablation atherectomy in a suboptimally expanded stent.

Methods

Seven pigs underwent suboptimal stent expansion in the left anterior descending coronary. Pulverization of the stent struts was performed by rotablation atherectomy with two different burr sizes. Two types of control porcine models were used: pigs with fully expanded stents and pigs without stents. Continuous electrocardiogram readings as well as microscopic and radiologic analysis of cardiac tissue were performed.

Results

Rotablation atherectomy reduces the suboptimally expanded stent by (26.95 ± 5.03)%. Ninety-five percent of the metal microparticles, imbedded in the suboptimally expanded stent group cardiac tissue, are less than 15 μm. Transient vasospasm and ST segments elevations were observed during rotablation atherectomy, which returned to basal conditions at the end of the intervention.

Conclusion

Our study demonstrated the feasibility and safety of using rotablation atherectomy to pulverize stent struts in a suboptimally expanded stent. © 2012 Wiley Periodicals, Inc.

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