Conflict of interest: Nothing to report.
Peripheral Vascular Disease
Renal artery duplex ultrasound criteria for the detection of significant in-stent restenosis
Article first published online: 14 NOV 2013
Copyright © 2013 Wiley Periodicals, Inc.
Catheterization and Cardiovascular Interventions
Volume 83, Issue 4, pages 612–618, 1 March 2014
How to Cite
del Conde, I., Galin, I. D., Trost, B., Kang, J., Lookstein, R., Woodward, M., Gustavson, S., Cambria, R. P., Jaff, M. R. and Olin, J. W. (2014), Renal artery duplex ultrasound criteria for the detection of significant in-stent restenosis. Cathet. Cardiovasc. Intervent., 83: 612–618. doi: 10.1002/ccd.25270
- Issue published online: 15 FEB 2014
- Article first published online: 14 NOV 2013
- Accepted manuscript online: 24 OCT 2013 04:13AM EST
- Manuscript Accepted: 18 OCT 2013
- Manuscript Received: 11 JUN 2013
- renal arteries
To define velocity criteria by ultrasonography for the detection of hemodynamically significant (>60%) renal artery in-stent restenosis (ISR).
The restenosis rate after renal artery stenting ranges between 10% and 20%. While duplex ultrasound criteria have been validated for native renal artery stenosis, there are no uniformly accepted validated criteria for stented renal arteries.
Vascular laboratory databases from two academic medical centers were retrospectively reviewed for patients who underwent renal artery stenting followed by duplex ultrasound evaluation and angiography (CT angiography or catheter angiography) as the gold standard.
A cohort of 132 stented renal arteries that had angiographic comparisons was analyzed. Eighty-eight renal arteries demonstrated 0–59% stenosis while 44 renal arteries revealed 60–99% stenosis by angiography. Both the mean peak systolic velocity (PSV) and the renal artery-to-aortic ratio (RAR) were significantly higher in renal arteries with 60–99% restenosis compared with those with 0–59% restenosis (PSV: 382 cm/sec ± 128 vs. 129 cm/sec ± 62, P<0.001; RAR: 5.3 ± 2.4 vs. 2.1 ± 1.0, P <0.001). The optimal PSV and RAR cutoffs for detecting 60–99% ISR were calculated by receiver operator characteristics curve analysis. The velocity criteria that are associated with these results will be discussed.
Duplex ultrasonography is an accurate technique to identify significant restenosis in stented renal arteries. The PSV and RAR cutoffs for detecting renal artery ISR are higher than those in native, unstented renal arteries. A normal duplex ultrasound after renal artery stenting virtually excludes significant restenosis. © 2013 Wiley Periodicals, Inc.