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Keywords:

  • aldol reaction;
  • amino acids;
  • amino alcohols;
  • asymmetric synthesis;
  • biocatalysis
Thumbnail image of graphical abstract

Broadened horizons: The application range of the long-known enzymatic enantio- and diastereoselective synthesis of β-hydroxy α-amino acids, a structural motif widely found in drug molecules and their intermediates, by means of an aldol reaction has recently been successfully expanded towards the asymmetric synthesis of α,α-disubstituted β-hydroxy α-amino acids and β-amino alcohols.