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Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of α-Methylated β-Hydroxy α-Amino Acids and β-Amino Alcohols



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Broadened horizons: The application range of the long-known enzymatic enantio- and diastereoselective synthesis of β-hydroxy α-amino acids, a structural motif widely found in drug molecules and their intermediates, by means of an aldol reaction has recently been successfully expanded towards the asymmetric synthesis of α,α-disubstituted β-hydroxy α-amino acids and β-amino alcohols.