One-Step Lactosylation of Hydrophobic Alcohols by Nonaqueous Biocatalysis

Authors

  • Yuri Okutani,

    1. Department of Forest and Forest Products Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 (Japan), Fax: (+81) 92-642-2993
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  • Shizuka Egusa,

    1. Department of Forest and Forest Products Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 (Japan), Fax: (+81) 92-642-2993
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  • Yukiko Ogawa Dr.,

    1. Department of Forest and Forest Products Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 (Japan), Fax: (+81) 92-642-2993
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  • Takuya Kitaoka Dr.,

    1. Department of Forest and Forest Products Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 (Japan), Fax: (+81) 92-642-2993
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  • Masahiro Goto Prof.,

    1. Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan)
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  • Hiroyuki Wariishi Prof.

    1. Department of Forest and Forest Products Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581 (Japan), Fax: (+81) 92-642-2993
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Abstract

original image

SEE delights: Alkyllactosides are successfully synthesized in a one-step enzymatic reaction from lactose in its original form and hydrophobic alcohols, by using a surfactant-enveloped enzyme (SEE) in nonaqueous 1,3-dimethyl-2-imidazolizinone, which can dissolve both donor sugars and acceptors. Nonaqueous biocatalysis is highly advantageous for efficient enzymatic glycosylation by SEE-mediated dehydration reaction.

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