Get access
Advertisement

Oxidoreductases Working Together: Concurrent Obtaining of Valuable Derivatives by Employing the PIKAT Method

Authors

  • Fabricio R. Bisogno,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author
  • Ana Rioz-Martínez,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author
  • Cristina Rodríguez Dr.,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author
  • Iván Lavandera Dr.,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author
  • Gonzalo de Gonzalo Dr.,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author
  • Daniel E. Torres Pazmiño Dr.,

    1. Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands)
    Search for more papers by this author
  • Marco W. Fraaije Prof. Dr.,

    1. Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands)
    Search for more papers by this author
  • Vicente Gotor Prof. Dr.

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-448
    Search for more papers by this author

Abstract

original image

Flying PIKATs: The stereoselective oxidation of several sulfides linked to the enantioselective oxidation of different sec-alcohols are combined in a parallel interconnected kinetic asymmetric transformation (PIKAT) fashion. Furthermore, the cofactor concentration employed in these processes is investigated, demonstrating a high capacity of performance, even at micromolar concentrations of the mediator.

Get access to the full text of this article

Ancillary