Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase
Article first published online: 15 JUL 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Biocatalysis
Volume 2, Issue 8, pages 953–957, August 9, 2010
How to Cite
Jing, Q. and Kazlauskas, Romas J. (2010), Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase. ChemCatChem, 2: 953–957. doi: 10.1002/cctc.201000159
- Issue published online: 30 JUL 2010
- Article first published online: 15 JUL 2010
- Manuscript Received: 11 MAY 2010
- U. of Minnesota
- General Mills Inc.
- protein engineering;
CA confidential: Replacing the active-site zinc in carbonic anhydrase (CA) by rhodium forms a new enzymatic catalyst for cofactor-free hydroformylation of styrene with syn gas. Unlike free rhodium, this rhodium–protein hybrid, [Rh]–CA, is regioselective (8.4:1) for linear over branched aldehyde product, which is a 40-fold change in regioselectivity compared to free rhodium.