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Keywords:

  • biocatalysis;
  • enzymes;
  • hydroformylation;
  • protein engineering;
  • rhodium
Thumbnail image of graphical abstract

CA confidential: Replacing the active-site zinc in carbonic anhydrase (CA) by rhodium forms a new enzymatic catalyst for cofactor-free hydroformylation of styrene with syn gas. Unlike free rhodium, this rhodium–protein hybrid, [Rh]–CA, is regioselective (8.4:1) for linear over branched aldehyde product, which is a 40-fold change in regioselectivity compared to free rhodium.