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Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase

  1. Qing Jing Dr.,
  2. Romas J. Kazlauskas Prof. Dr.

Article first published online: 15 JUL 2010

DOI: 10.1002/cctc.201000159

Issue

ChemCatChem

ChemCatChem

Special Issue: Biocatalysis

Volume 2, Issue 8, pages 953–957, August 9, 2010

Additional Information

How to Cite

Jing, Q. and Kazlauskas, Romas J. (2010), Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase. ChemCatChem, 2: 953–957. doi: 10.1002/cctc.201000159

Author Information

  1. Department of Biochemistry, Molecular Biology & Biophysics and the Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, MN 55108 (USA), Fax: (+1) 612-625-5780

Publication History

  1. Issue published online: 30 JUL 2010
  2. Article first published online: 15 JUL 2010
  3. Manuscript Received: 11 MAY 2010

Funded by

  • U. of Minnesota
  • General Mills Inc.

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Keywords:

  • biocatalysis;
  • enzymes;
  • hydroformylation;
  • protein engineering;
  • rhodium
Thumbnail image of graphical abstract

CA confidential: Replacing the active-site zinc in carbonic anhydrase (CA) by rhodium forms a new enzymatic catalyst for cofactor-free hydroformylation of styrene with syn gas. Unlike free rhodium, this rhodium–protein hybrid, [Rh]–CA, is regioselective (8.4:1) for linear over branched aldehyde product, which is a 40-fold change in regioselectivity compared to free rhodium.

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