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Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase

Authors

  • Qing Jing Dr.,

    1. Department of Biochemistry, Molecular Biology & Biophysics and the Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, MN 55108 (USA), Fax: (+1) 612-625-5780
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  • Romas J. Kazlauskas Prof. Dr.

    1. Department of Biochemistry, Molecular Biology & Biophysics and the Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, MN 55108 (USA), Fax: (+1) 612-625-5780
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Abstract

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CA confidential: Replacing the active-site zinc in carbonic anhydrase (CA) by rhodium forms a new enzymatic catalyst for cofactor-free hydroformylation of styrene with syn gas. Unlike free rhodium, this rhodium–protein hybrid, [Rh]–CA, is regioselective (8.4:1) for linear over branched aldehyde product, which is a 40-fold change in regioselectivity compared to free rhodium.

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