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Keywords:

  • cyclization;
  • homogeneous catalysis;
  • molecular capsules;
  • self-assembly;
  • supramolecular chemistry
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Enzyme-like catalysis of Nazarov cyclizations has been achieved by encapsulation of pentadienols into a metallosupramolecular capsule. Constrictive binding of the substrate and functional-group activation give rise to a tremendous rate acceleration of up to a factor of 2.1×106, thus, pushing the efficiency of self-assembled molecular capsules as catalysts to a new level.