Functionalized Grignard Reagents in Kumada Cross-Coupling Reactions



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Hakuna Kumada: Several efficient Kumada cross-coupling protocols of functionalized arylmagnesium halides and functionalized aryl and alkyl halides have been recently reported, including the first examples of the catalytic asymmetric Kumada coupling of racemic secondary alkyl halides. These procedures dramatically improve the synthetic potential of the Kumada cross-coupling reaction.