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Keywords:

  • asymmetric synthesis;
  • cross-coupling;
  • Grignard reagent;
  • homogeneous catalysis;
  • Kumada coupling
Thumbnail image of graphical abstract

Hakuna Kumada: Several efficient Kumada cross-coupling protocols of functionalized arylmagnesium halides and functionalized aryl and alkyl halides have been recently reported, including the first examples of the catalytic asymmetric Kumada coupling of racemic secondary alkyl halides. These procedures dramatically improve the synthetic potential of the Kumada cross-coupling reaction.