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The Aminohydroxylation of Alkenes Breaks New Ground

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Abstract

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Iron & copper: Impressive developments have recently been made in the field of direct aminohydroxylation of olefins for the synthesis of versatile β-amino alcohol building blocks. Oxaziridines as new sources of both N and O atoms exhibit excellent reactivity and substrate scope under copper and iron catalysis. The choice of catalyst governs regiocontrol in the addition to olefins. Best selectivities have been achieved with styrenes and 1,3-dienes.

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