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Keywords:

  • asymmetric catalysis;
  • hydrogenation;
  • imines;
  • iridium;
  • methylaluminoxane
Thumbnail image of graphical abstract

An ionic revolution? BArF has been the anion of choice for iridium-catalyzed imine hydrogenation; however, for large-scale production its use may be too costly. Methylaluminoxane (MAO) can be used instead in conjunction with [{Ir(COD)Cl}2], although enantioselectivities are somewhat lower than with BArF if 50–500 eq. of MAO are used.