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Nickel-Catalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride (Lithium Triethylborohydride)

Authors

  • Jingjing Wu,

    1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237 (China), Fax: (+86) 21-6425-2603
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  • Prof. Song Cao

    Corresponding author
    1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237 (China), Fax: (+86) 21-6425-2603
    • Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237 (China), Fax: (+86) 21-6425-2603
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Abstract

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Superkiller of C[BOND]F bonds: Two new LiEt3BH/Ni-based catalyst systems for the hydrodefluorination (HDF) of fluoroarenes and trifluorotoluenes were reported. Both fluoroarenes and trifluorotoluenes were reduced to the corresponding arenes and toluenes in excellent yields with LiEt3BH in the presence of 40 % NiCl2, whereas a catalytic amount of NiCl2(PCy3)2 (typically 5 mol %) along with LiEt3BH exhibited high activity and selectivity in the HDF of fluoroarenes and was inert to trifluorotoluenes.

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