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Facile Hydrogenation of Ketones Catalyzed by Platinum on Carbon under Ordinary Pressures and Temperatures

Authors

  • Dr. Yuta Fujiwara,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
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  • Youhei Iwasaki,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
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  • Dr. Tomohiro Maegawa,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
    2. Current address: Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamada-oka, Suita, Osaka 565-0871 (Japan)
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  • Dr. Yasunari Monguchi,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
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  • Prof. Dr. Hironao Sajiki

    Corresponding author
    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
    • Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8100
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Abstract

An efficient and practical procedure for the hydrogenation of aliphatic and aromatic ketones under mild reaction conditions is established. The method is highly effective even for the hydrogenation of sterically hindered ketones. Furthermore, the selective hydrogenation of the carbonyl group of aromatic ketones was achieved with the aromatic nuclei and the resulting secondary benzyl alcohol moiety still intact on addition of catalytic amount of pyridine.

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