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Organocatalytic Asymmetric Additions to meso-Anhydrides and Azlactones

Authors

  • Dr. Zaida Rodriguez-Docampo,

    1. Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2 (Ireland), Fax: (+353) 1-6712826
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  • Prof. Stephen J. Connon

    Corresponding author
    1. Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2 (Ireland), Fax: (+353) 1-6712826
    • Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2 (Ireland), Fax: (+353) 1-6712826

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Abstract

This review charts the recent progress of two related, yet distinct organocatalytic processes: the desymmetrisation of meso-anhydrides and the dynamic kinetic resolution of azlactones. Driven by recent advances in catalyst design, both these processes have undergone something of a renaissance in recent years and are now becoming very powerful and versatile synthetic methodologies. The material is presented in a critical fashion and the material is organised by reaction type and catalyst class.

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