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Keywords:

  • amides;
  • carbonylation;
  • ammonia;
  • benzyl chlorides;
  • palladium
Thumbnail image of graphical abstract

Don't moan, use Ammonia! A general palladium-catalyzed aminocarbonylation of benzyl chlorides using ammonia has been developed. Various primary 2-arylacetamides are synthesized in good to excellent yields and selectivities by using an inexpensive palladium catalyst system for this atom-efficient methodology.