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Keywords:

  • homogeneous catalysis;
  • oxidative coupling;
  • quinolines;
  • vanadium
Thumbnail image of graphical abstract

In the THIQ of it:N-Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m-CPBA and [VO(acac)2]. This method has been applied to the synthesis of the opioid methopholine.