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C1-Substituted N-Alkyl Tetrahydroisoquinoline Derivatives through V-Catalyzed Oxidative Coupling

  1. Dr. Kevin M. Jones1,
  2. Pol Karier1,2,
  3. Dr. Martin Klussmann1,*

Article first published online: 14 NOV 2011

DOI: 10.1002/cctc.201100324

Issue

ChemCatChem

ChemCatChem

Volume 4, Issue 1, pages 51–54, January 2, 2012

Additional Information

How to Cite

Jones, K. M., Karier, P. and Klussmann, M. (2012), C1-Substituted N-Alkyl Tetrahydroisoquinoline Derivatives through V-Catalyzed Oxidative Coupling. ChemCatChem, 4: 51–54. doi: 10.1002/cctc.201100324

Author Information

  1. 1

    Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)

  2. 2

    Current address: Université catholique de Louvain, Bâtiment Lavoisier, Place Louis Pasteur, 1, bte 2B-1348, Louvain-la-Neuve (Belgium)

*Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)

Publication History

  1. Issue published online: 27 DEC 2011
  2. Article first published online: 14 NOV 2011
  3. Manuscript Received: 15 SEP 2011

Funded by

  • Max-Planck-Institut
  • Alexander von Humboldt-foundation

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Keywords:

  • homogeneous catalysis;
  • oxidative coupling;
  • quinolines;
  • vanadium
Thumbnail image of graphical abstract

In the THIQ of it:N-Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m-CPBA and [VO(acac)2]. This method has been applied to the synthesis of the opioid methopholine.

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