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C1-Substituted N-Alkyl Tetrahydroisoquinoline Derivatives through V-Catalyzed Oxidative Coupling

Authors

  • Dr. Kevin M. Jones,

    1. Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)
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  • Pol Karier,

    1. Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)
    2. Current address: Université catholique de Louvain, Bâtiment Lavoisier, Place Louis Pasteur, 1, bte 2B-1348, Louvain-la-Neuve (Belgium)
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  • Dr. Martin Klussmann

    Corresponding author
    1. Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)
    • Max-Planck-Institut fuer Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Muelheim an der Ruhr (Germany)
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Abstract

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In the THIQ of it:N-Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m-CPBA and [VO(acac)2]. This method has been applied to the synthesis of the opioid methopholine.

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